美国诺华生物医药研究中心研究员喻勇博士应邀来我院作学术报告
4月19日下午，应生工院的邀请，美国诺华生物医药研究中心研究员喻勇博士来我院作了 《Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC》学术报告，院长吴晓玉教授主持报告会，朱向东博士介绍了喻勇博士的主要科研成果。生工院教师及研究生60余人听取了报告。
喻勇博士首先介绍了自己在国内和国外的学习与工作经历，以及在国内国外所从事的科学研究概况，为生工院师生作了一场很有专业深度和专业前瞻性的学术报告，并就自己所从事的生物医药研究与生工院师生展开了深入的探讨。喻勇博士的报告在生工院师生中引起强烈反响。报告结束后，喻勇博士与生工院师生围绕报告内容进行了真诚和热烈的交流。报告与交流时间长达二个半小时。
喻勇博士曾在江西农业大学农学院完成本科学业并留校工作。(生工院办)
附：喻勇博士学习、工作简介：
CURRICULUM VITAE Robert Yong Yu, PhD
Education
· Ph.D., Biochemistry, Kansas State University, Manhattan, Kansas, U. S. A, June 1998
· M.S., Microbiology, Chinese Academy of Agricultural Sciences, Beijing, China , July 1990
· B.S., Agronomy, Jiangxi Agricultural University, Jiangxi, China , July 1984
Research Experience
Novartis Institutes for BioMedical Research
Cambridge, Massachusetts, 2008-present
Boston University
Research associate, Boston, Massachusetts, Aug. 2003 –April, 2008
Pharmadyne Inc.
Scientist, Boston, Massachusetts, May, 2001-July, 2003
Boston University
Research associate, Boston, Massachusetts, July 1998 –May 2001
Kansas State University, Biochemistry Department
Graduate Research Assistant, Manhattan, Kansas, Fall 1993-July 1998,
Jiangxi Agricultural University, Agronomy Department
Assistant Professor, Jiangxi, China, Fall 1990-Spring 1993
Chinese Academy of Agricultural Sciences, Soils and Fertilizers Institute
Graduate Research Assistant, Beijing, China, Spring 1988-Spring 1990
Jiangxi Agricultural University, Agronomy Department
Research Assistant, Jiangxi, China,Fall 1984-Spring 1987,
Teaching Experience
Kansas State University
· General Biochemistry Lab, Instructor, Summer 1997
· Biochemistry I Lab, Teaching Assistant, Spring 1996 and Spring 1995
· Biochemistry II Lab, Teaching Assistant, Fall 1995
· General Biochemistry Lab, Teaching Assistant, Fall 1993- Fall 1995
Jiangxi Agricultural University
· Microbiology of Methane Fermentation, Instructor, Fall 1991-Spring 1992
· Microbiology, Instructor, Fall 1990-Spring 1993
· Agricultural English, Instructor, Fall 1990-Spring 1993
· Microbiology Lab, Instructor, Fall 1984-Spring 1987
Publications
Nyfeler B, Hoepfner D, Palestrant D, Kirby CA, Whitehead L, Yu R, Deng G, Caughlan RE, Woods AL, Jones AK, Barnes SW, Walker JR, Gaulis S, Hauy E, Brachmann SM, Krastel P, Studer C, Riedl R, Estoppey D, Aust T, Movva NR, Wang Z, Salcius M, Michaud GA, McAllister G, Murphy LO, Tallarico JA, Wilson CJ, Dean CR. Identification of elongation factor G as the conserved cellular target of argyrin B. PLoS One. 2012;7(9):e42657.
Pierce B., Haidar J., Yu Y., and Weng Z. Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains. Biochemistry. 2010 Aug 24;49(33):7050-9.
Haidar J., Pierce B., Yu Y., Tong W., Li M., and Weng Z. Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC. Proteins. 2009 Mar;74(4):948-60.
ENCODE Project Consortium (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447(7146):799-816.
Xi H., Yu Y., Foley J. E., Halees A., Weng Z. (2007). Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1. Genome Research. 17(6):798-806.
Aslan F.M., Yu Y., Vajda S., Mohr S. C., Cantor C. R. (2007). Engineering a novel, stable dimeric streptavidin with lower isoelectric point. J Biotechnol. 128(2):213-25.
Demidov V. V., Dokholyan N.V., Witte-Hoffmann C., Chalasani P., Yiu H. W., Ding F., Yu Y., Cantor C. R., Broude N. E. (2006). Fast complementation of split fluorescent protein triggered by DNA hybridization. Proc Natl Acad Sci U S A. 103(7):2052-6.
Aslan F. M., Yu Y., Mohr S.C., Cantor C.R. (2005). Engineered single-chain dimeric streptavidins with an unexpected strong preference for biotin-4-fluorescein. Proc Natl Acad Sci U S A. 102(24):8507-8512.
Yanai I. Yu Y., Zhu X., Cantor C. R., and Weng Z. (2005). An avidin-like domain that does not bind biotin is adopted for oligomerization by the extracellular mosaic protein fibropellin. Protein Science. 14(2):417-23.
The ENCODE Project Consortium (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306, 636-640.
Reznik G. O., Yu Y., Tarr G. E., Cantor C. R.. (2003). Native disulfide bonds in plasma retinol-binding protein are not essential for all-trans-retinol-binding activity. Journal of Proteome Research. 2(3):243-8.
Zou L., Baguinon M. C., Guo X., Guo S. Y., Yu Y., Davis L. C.. (2000) Interaction with Magnesium and ADP Stabilizes Both Components of Nitrogenase from Klebsiella pneumoniae against Urea Denaturation. Protein Science. 9:121-128.
Yu Y., C. Ge, L. M. Xu, and H. Fan (1992) A Study on the Plasmid Profiles of Sinorhizobium fredii from Different Geographical Origins. Scientia Agricultura Sinica. 25(3): 14-21.
